Revue du rôle possible de la vitamine D dans le traitement de la COVID-19 et recommandations pratiques

Poulin, David

doi:https://doi.org/10.7202/1084270ar

1. Chen P-L, Lee N-Y, Cia C-T, Ko W-C, Hsueh P-R. A Review of Treatment of Coronavirus Disease 2019 (COVID-19): Therapeutic Repurposing and Unmet Clinical Needs. Front Pharmacol. 2020 ;11:584956.

10.3389/fphar.2020.584956 Google Scholar

2. World Health Organization. Therapeutics and COVID-19: living guideline [En ligne]. 2021 [cité le 9 avril 2021 ]. Disponible : https://www.who.int/publications/i/item/WHO-2019-nCoV-therapeutics-2021.1.

Google Scholar

3. Martineau AR, Forouhi NG. Vitamin D for COVID-19: a case to answer ? The Lancet Diabetes & Endocrinology. 2020 ;8(9):735-6.

10.1016/S2213-8587(20)30268-0 Google Scholar

4. Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014 ;21(3):319-29.

10.1016/j.chembiol.2013.12.016 Google Scholar

5. Marino R, Misra M. Extra-Skeletal Effects of Vitamin D. Nutrients. 2019 ;11(7):1460.

10.3390/nu11071460 Google Scholar

6. Wacker M, Holick MF. Vitamin D – effects on skeletal and extraskeletal health and the need for supplementation. Nutrients. 2013 ;5(1):111-48.

10.3390/nu5010111 Google Scholar

7. Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Reviews in Endocrine and Metabolic Disorders. 2017 ;18(2):153-65.

10.1007/s11154-017-9424-1 Google Scholar

8. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et coll. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. The Journal of clinical endocrinology and metabolism. 2011 ;96(1):53-8.

10.1016/j.jada.2011.01.004 Google Scholar

9. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology & Metabolism. 2011 ;96(7):1911-30.

10.1210/jc.2011-0385 Google Scholar

10. Gilbert CR, Arum SM, Smith CM. Vitamin D deficiency and chronic lung disease. Can Respir J. 2009 ;16(3):75-80.

10.1155/2009/829130 Google Scholar

11. Dancer RC, Parekh D, Lax S, D’Souza V, Zheng S, Bassford CR, et al. Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS). Thorax. 2015 ;70(7):617-24.

10.1136/thoraxjnl-2014-206680 Google Scholar

12. Jolliffe DA, Greenberg L, Hooper RL, Griffiths CJ, Camargo CA, Kerley CP, et al. Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data. Lancet Respir Med. 2017 ;5(11):881-90.

10.1016/S2213-2600(17)30306-5 Google Scholar

13. Zhu M, Wang T, Wang C, Ji Y. The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta-analysis. International journal of chronic obstructive pulmonary disease. 2016 ;11:2597-607.

10.2147/COPD.S101382 Google Scholar

14. Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ (Clinical research ed). 2017 ;356:i6583.

10.1136/bmj.i6583 Google Scholar

15. Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review. JAMA. 2020 ;324(8):782-93.

10.1001/jama.2020.12839 Google Scholar

16. Zambrano LD, Ellington S, Strid P, Galang RR, Oduyebo T, Tong VT, et coll. Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status - United States, January 22-October 3, 2020. MMWR Morb Mortal Wkly Rep. 2020 ;69(44):1641-7.

10.15585/mmwr.mm6925a1 Google Scholar

17. Malek Mahdavi A. A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19. Reviews in medical virology. 2020 ;30(5):e2119.

10.1002/rmv.2119 Google Scholar

18. Greiller CL, Martineau AR. Modulation of the immune response to respiratory viruses by vitamin D. Nutrients. 2015 ;7(6):4240-70.

10.3390/nu7064240 Google Scholar

19. Hansdottir S, Monick MM. Vitamin D effects on lung immunity and respiratory diseases. Vitam Horm. 2011 ;86:217-37.

10.1016/B978-0-12-386960-9.00009-5 Google Scholar

20. Bleizgys A. Vitamin D and COVID-19: It is time to act. International Journal of Clinical Practice. 2020 ;75:e13748.

10.1111/ijcp.13748 Google Scholar

21. Chen H, Lu R, Zhang Y-G, Sun J. Vitamin D Receptor Deletion Leads to the Destruction of Tight and Adherens Junctions in Lungs. Tissue Barriers. 2018 ;6(4):1-13.

10.1080/21688370.2018.1540904 Google Scholar

22. Rehan VK, Torday JS, Peleg S, Gennaro L, Vouros P, Padbury J, et al. 1Alpha,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxy vitamin D3: production and biological activity studies in pulmonary alveolar type II cells. Molecular genetics and metabolism. 2002 ;76(1):46-56.

10.1016/S1096-7192(02)00022-7 Google Scholar

23. Merzon E, Tworowski D, Gorohovski A, Vinker S, Golan Cohen A, Green I, et al. Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study. FEBS J. 2020 ;287(17):3693-702.

10.1111/febs.15495 Google Scholar

24. Mardani R, Alamdary A, Mousavi Nasab SD, Gholami R, Ahmadi N, Gholami A. Association of vitamin D with the modulation of the disease severity in COVID-19. Virus Research. 2020 ;289:198148.

10.1016/j.virusres.2020.198148 Google Scholar

25. Baktash V, Hosack T, Patel N, Shah S, Kandiah P, Van den Abbeele K, et al. Vitamin D status and outcomes for hospitalised older patients with COVID-19. Postgraduate medical journal. 2020 ;138712.

10.1136/postgradmedj-2020-138712 Google Scholar

26. Liu N, Sun J, Wang X, Zhang T, Zhao M, Li H. Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis. International Journal of Infectious Diseases. 2021 ;104:58-64.

10.1016/j.ijid.2020.12.077 Google Scholar

27. Hernández JL, Nan D, Fernandez-Ayala M, García-Unzueta M, Hernández-Hernández MA, López-Hoyos M, et al. Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection. The Journal of clinical endocrinology and metabolism. 2021 ;106(3):e1343-e53.

10.1210/clinem/dgaa733 Google Scholar

28. Im JH, Je YS, Baek J, Chung M-H, Kwon HY, Lee J-S. Nutritional status of patients with COVID-19. Int J Infect Dis. 2020 ;100:390-3.

10.1016/j.ijid.2020.08.018 Google Scholar

29. Ye K, Tang F, Liao X, Shaw BA, Deng M, Huang G, et al. Does Serum Vitamin D Level Affect COVID-19 Infection and Its Severity ?-A Case-Control Study. Journal of the American College of Nutrition [En ligne]. 13 oct 2020 [cité le 20 mars 2021]:[environ 8 p.] Disponible : https://www.tandfonline.com/doi/full/10.1080/07315724.2020.1826005

10.1080/07315724.2020.1826005 Google Scholar

30. Abdollahi A, Kamali Sarvestani H, Rafat Z, Ghaderkhani S, Mahmoudi-Aliabadi M, Jafarzadeh B, et al. The association between the level of serum 25(OH) vitamin D, obesity, and underlying diseases with the risk of developing COVID-19 infection: A case–control study of hospitalized patients in Tehran, Iran. Journal of medical virology. 2021 ;93(4):2359-64.

10.1002/jmv.26726 Google Scholar

31. Sulli A, Gotelli E, Casabella A, Paolino S, Pizzorni C, Alessandri E, et al. Vitamin D and Lung Outcomes in Elderly COVID-19 Patients. Nutrients. 2021 ;13(3):717.

10.3390/nu13030717 Google Scholar

32. Luo X, Liao Q, Shen Y, Li H, Cheng L. Vitamin D Deficiency Is Inversely Associated with COVID-19 Incidence and Disease Severity in Chinese People. The Journal of nutrition. 2021 ;151(1):98-103.

10.1093/jn/nxaa332 Google Scholar

33. Pereira M, Dantas Damascena A, Galvão Azevedo LM, de Almeida Oliveira T, da Mota Santana J. Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis. Critical reviews in food science and nutrition [En ligne]. 4 nov 2020 [cité le 20 mars 2021]:[environ 9 p.] Disponible : https://www.tandfonline.com/doi/full/10.1080/10408398.2020.1841090.

10.1080/10408398.2020.1841090 Google Scholar

34. D’Avolio A, Avataneo V, Manca A, Cusato J, De Nicolò A, Lucchini R, et coll. 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2. Nutrients. 2020 ;12(5):1359.

10.3390/nu12051359 Google Scholar

35. Hastie CE, Mackay DF, Ho F, Celis-Morales CA, Katikireddi SV, Niedzwiedz CL, et al. Vitamin D concentrations and COVID-19 infection in UK Biobank. Diabetes Metab Syndr. 2020 ;14(4):561-5.

10.1016/j.dsx.2020.04.050 Google Scholar

36. Kaufman HW, Niles JK, Kroll MH, Bi C, Holick MF. SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels. PloS one. 2020 ;15(9):e0239252.

10.1371/journal.pone.0239252 Google Scholar

37. Meltzer DO, Best TJ, Zhang H, Vokes T, Arora V, Solway J. Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results. JAMA Network Open. 2020 ;3(9):e2019722.

10.1001/jamanetworkopen.2020.19722 Google Scholar

38. Katz J, Yue S, Xue W. Increased risk for COVID-19 in patients with vitamin D deficiency. Nutrition. 2020 ;84:111106.

10.1016/j.nut.2020.111106 Google Scholar

39. Amin HA, Drenos F. No evidence that vitamin D is able to prevent or affect the severity of COVID-19 in individuals with European ancestry: a Mendelian randomisation study of open data. BMJ Nutr Prev Health. 2021:bmjnph-2020-000151.

10.1136/bmjnph-2020-000151 Google Scholar

40. Orchard L, Baldry M, Nasim-Mohi M, Monck C, Saeed K, Grocott MPW, Ahilanandan D. Vitamin-D levels and intensive care unit outcomes of a cohort of critically ill COVID-19 patients. Clin Chem Lab Med. 2021 Jan 19 ;59(6):1155-1163.

10.1515/cclm-2020-1567 Google Scholar

41. Radujkovic A, Hippchen T, Tiwari-Heckler S, Dreher S, Boxberger M, Merle U. Vitamin D Deficiency and Outcome of COVID-19 Patients. Nutrients. 2020 ;12(9).

10.3390/nu12092757 Google Scholar

42. Gavioli EM, Miyashita H, Hassaneen O, Siau E. An Evaluation of Serum 25-Hydroxy Vitamin D Levels in Patients with COVID-19 in New York City. Journal of the American College of Nutrition [En ligne]. 19 fév 2021[cité le 20 mars 2021]:[environ 6 p.]. Disponible : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898298/

10.1080/07315724.2020.1869626 Google Scholar

43. Angelidi AM, Belanger MJ, Lorinsky MK, Karamanis D, Chamorro-Pareja N, Ognibene J, et al. Vitamin D Status Is Associated With In-Hospital Mortality and Mechanical Ventilation: A Cohort of COVID-19 Hospitalized Patients. Mayo Clinic Proceedings. 2021 ;96(4):875-86.

10.1016/j.mayocp.2021.01.001 Google Scholar

44. Jain A, Chaurasia R, Sengar NS, Singh M, Mahor S, Narain S. Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers. Scientific Reports. 2020 ;10(1):20191.

10.1038/s41598-020-77093-z Google Scholar

45. Abrishami A, Dalili N, Mohammadi Torbati P, Asgari R, Arab-Ahmadi M, Behnam B, Sanei-Taheri M. Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective study. Eur J Nutr. 2021 Jun ;60(4):2249-2257.

10.1007/s00394-020-02411-0 Google Scholar

46. Ricci A, Pagliuca A, D’Ascanio M, Innammorato M, De Vitis C, Mancini R, et al. Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients. Respiratory research. 2021 ;22(1):76.

10.1186/s12931-021-01666-3 Google Scholar

47. Demir M, Demir F, Aygun H. Vitamin D deficiency is associated with COVID-19 positivity and severity of the disease. Journal of medical virology. 2021 ;93(5):2992-9.

10.1002/jmv.26832 Google Scholar

48. Basaran N, Adas M, Gokden Y, Turgut N, Yildirmak T, Guntas G. The relationship between vitamin D and the severity of COVID-19. Bratislavske lekarske listy. 2021 ;122(3):200-5.

10.4149/BLL_2021_034 Google Scholar

49. Munshi R, Hussein MH, Toraih EA, Elshazli RM, Jardak C, Sultana N, et al. Vitamin D insufficiency as a potential culprit in critical COVID-19 patients. Journal of medical virology. 2021 ;93(2):733-40.

10.1002/jmv.26360 Google Scholar

50. Lohia P, Nguyen P, Patel N, Kapur S. Exploring the link between vitamin D and clinical outcomes in COVID-19. American journal of physiology Endocrinology and metabolism. 2021 ;320(3):E520-e6.

10.1152/ajpendo.00517.2020 Google Scholar

51. Cereda E, Bogliolo L, Klersy C, Lobascio F, Masi S, Crotti S, et al. Vitamin D 25OH deficiency in COVID-19 patients admitted to a tertiary referral hospital. Clinical nutrition (Edinburgh, Scotland). 2020 ;40(4):2469-72.

10.1016/j.clnu.2020.10.055 Google Scholar

52. Pizzini A, Aichner M, Sahanic S, Böhm A, Egger A, Hoermann G, et al. Impact of Vitamin D Deficiency on COVID-19-A Prospective Analysis from the CovILD Registry. Nutrients. 2020 ;12(9).

10.3390/nu12092775 Google Scholar

53. Szeto B, Zucker JE, LaSota ED, Rubin MR, Walker MD, Yin MT, Cohen A. Vitamin D Status and COVID-19. Clinical Outcomes in Hospitalized Patients. Endocr Res. 2021 Feb-May ;46(2):66-73.

10.1080/07435800.2020.1867162 Google Scholar

54. Karahan S, Katkat F. Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey. The journal of nutrition, health & aging. 2021 ;25(2):189-96.

10.1007/s12603-020-1479-0 Google Scholar

55. Vassiliou AG, Jahaj E, Pratikaki M, Orfanos SE, Dimopoulou I, Kotanidou A. Low 25-Hydroxyvitamin D Levels on Admission to the Intensive Care Unit May Predispose COVID-19 Pneumonia Patients to a Higher 28-Day Mortality Risk: A Pilot Study on a Greek ICU Cohort. Nutrients. 2020 ;12(12):3773.

10.3390/nu12123773 Google Scholar

56. Infante M, Buoso A, Pieri M, Lupisella S, Nuccetelli M, Bernardini S, et coll. Low Vitamin D Status at Admission as a Risk Factor for Poor Survival in Hospitalized Patients With COVID-19: An Italian Retrospective Study. Journal of the American College of Nutrition [En ligne]. 18 fév 2021 [cité le 20 mars 2021]:[environ 16 p.]. Disponible : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899172/

10.1080/07315724.2021.1877580 Google Scholar

57. De Smet D, De Smet K, Herroelen P, Gryspeerdt S, Martens GA. Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality. American journal of clinical pathology. 2021 ;155(3):381-8.

10.1093/ajcp/aqaa252 Google Scholar

58. Carpagnano GE, Di Lecce V, Quaranta VN, Zito A, Buonamico E, Capozza E, et al. Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19. J Endocrinol Invest. 2021 ;44(4):765-71.

10.1007/s40618-020-01370-x Google Scholar

59. Bennouar S, Cherif AB, Kessira A, Bennouar D-E, Abdi S. Vitamin D Deficiency and Low Serum Calcium as Predictors of Poor Prognosis in Patients with Severe COVID-19. Journal of the American College of Nutrition. 2021 ;40(2):104-10.

10.1080/07315724.2020.1856013 Google Scholar

60. Hastie CE, Pell JP, Sattar N. Vitamin D and COVID-19 infection and mortality in UK Biobank. Eur J Nutr. 2021 ;60(1):545-8.

10.1007/s00394-020-02372-4 Google Scholar

61. Arvinte C, Singh M, Marik PE. Serum Levels of Vitamin C and Vitamin D in a Cohort of Critically Ill COVID-19 Patients of a North American Community Hospital Intensive Care Unit in May 2020: A Pilot Study. Med Drug Discov. 2020 ;8:100064.

10.1016/j.medidd.2020.100064 Google Scholar

62. Silva MC, Furlanetto TW. Does serum 25-hydroxyvitamin D decrease during acute-phase response ? A systematic review. Nutrition Research. 2015 ;35(2):91-6.

10.1016/j.nutres.2014.12.008 Google Scholar

63. NIH. Clinicaltrials.gov [En ligne]. 2020 [cité le 20 mars 2021 ]. Disponible : https://clinicaltrials.gov/ct2/results?cond=SARS-CoV-2&term=vitamin+D&cntry=&state=&city=&dist=&Search=Search&type=Intr

Google Scholar

64. Entrenas Castillo M, Entrenas Costa LM, Vaquero Barrios JM, Alcalá Díaz JF, López Miranda J, Bouillon R, et al. «Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study». J Steroid Biochem Mol Biol. 2020 ;203:105751.

10.1016/j.jsbmb.2020.105751 Google Scholar

65. Rastogi A, Bhansali A, Khare N, Suri V, Yaddanapudi N, Sachdeva N, et al. Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study). Postgraduate Medical Journal. 2020:postgradmedj-2020-139065.

10.1136/postgradmedj-2020-139065 Google Scholar

66. CDC. Interim guidance on duration of isolation and precautions for adults with COVID-19 [En ligne]. 2021 [cité le 20 mars 2021]. Disponible : https://www.cdc.gov/coronavirus/2019-ncov/hcp/duration-isolation.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fcommunity%2Fstrategy-discontinue-isolation.html#references

Google Scholar

67. Murai IH, Fernandes AL, Sales LP, Pinto AJ, Goessler KF, Duran CSC, et al. Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial. JAMA. 2021 ;325(11):1053-60.

10.1001/jama.2020.26848 Google Scholar

68. Annweiler C, Hanotte B, Grandin de l’Eprevier C, Sabatier J-M, Lafaie L, Célarier T. Vitamin D and survival in COVID-19 patients : A quasi-experimental study. J Steroid Biochem Mol Biol. 2020 ;204:105771.

10.1016/j.jsbmb.2020.105771 Google Scholar

69. Ling SF, Broad E, Murphy R, Pappachan JM, Pardesi-Newton S, Kong MF, et al. High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study. Nutrients. 2020 ;12(12):3799.

10.3390/nu12123799 Google Scholar

70. Tan CW, Ho LP, Kalimuddin S, Cherng BPZ, Teh YE, Thien SY, et al. Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19). Nutrition. 2020 ;79-80:111017.

10.1016/j.nut.2020.111017 Google Scholar

71. Annweiler G, Corvaisier M, Gautier J, Dubée V, Legrand E, Sacco G, et coll. Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study. Nutrients. 2020 ;12(11):3377.

10.3390/nu12113377 Google Scholar

72. Giannini S, Passeri G, Tripepi G, Sella S, Fusaro M, Arcidiacono G, et al. Effectiveness of In-Hospital Cholecalciferol Use on Clinical Outcomes in Comorbid COVID-19 Patients: A Hypothesis-Generating Study. Nutrients. 2021 ;13(1):219.

10.3390/nu13010219 Google Scholar

73. Cereda E, Bogliolo L, Lobascio F, Barichella M, Zecchinelli AL, Pezzoli G, et al. Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy. Nutrition. 2021 ;82:111055.

10.1016/j.nut.2020.111055 Google Scholar

74. Shah K, Saxena D, Mavalankar D. Vitamin D supplementation, COVID-19 and disease severity: a meta-analysis. QJM: An International Journal of Medicine. 2021 ;hcab009.

10.1093/qjmed/hcab009 Google Scholar

75. Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020 ;12(4):988.

10.3390/nu12040988 Google Scholar

76. Chakhtoura M, Napoli N, El Hajj Fuleihan G. Commentary: Myths and facts on vitamin D amidst the COVID-19 pandemic. Metabolism. 2020 ;109:154276.

10.1016/j.metabol.2020.154276 Google Scholar

77. Ali N. Role of vitamin D in preventing of COVID-19 infection, progression and severity. Journal of Infection and Public Health. 2020 ;13(10):1373-80.

10.1016/j.jiph.2020.06.021 Google Scholar

78. Bergman P. The link between vitamin D and COVID-19: distinguishing facts from fiction. Journal of internal medicine. 2021 ;289(1):131-3.

10.1111/joim.13158 Google Scholar

79. Ferder L, Martín Giménez VM, Inserra F, Tajer C, Antonietti L, Mariani J, et coll. Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic. American journal of physiology Lung cellular and molecular physiology. 2020 ;319(6):L941-l8.

10.1152/ajplung.00186.2020 Google Scholar

80. Sahebnasagh A, Saghafi F, Avan R, Khoshi A, Khataminia M, Safdari M, et al. The prophylaxis and treatment potential of supplements for COVID-19. European Journal of Pharmacology. 2020 ;887:173530.

10.1016/j.ejphar.2020.173530 Google Scholar

81. Chandran M, Chan Maung A, Mithal A, Parameswaran R. Vitamin D in COVID - 19: Dousing the fire or averting the storm ? –A perspective from the Asia-Pacific. Osteoporosis and Sarcopenia. 2020 ;6(3):97-105.

10.1016/j.afos.2020.07.003 Google Scholar

82. Ebadi M, Montano-Loza AJ. Perspective: improving vitamin D status in the management of COVID-19. European journal of clinical nutrition. 2020 ;74(6):856-9.

10.1038/s41430-020-0661-0 Google Scholar

83. Santé Canada. La vitamine D et le calcium : Révision des Apports nutritionnels de référence [En ligne]. 2020 [cité le 9 avril 2021]. Disponible : https://www.canada.ca/fr/sante-canada/services/aliments-nutrition/saine-alimentation/vitamines-mineraux/vitamine-calcium-revision-apports-nutritionnels-reference.html

Google Scholar

84. Alberta Health Services. COVID-19 Scientific Advisory Group Rapid Evidence Brief. Vitamin D in the Treatment and Prevention of COVID-19 [En ligne]. 2020 [cité le 9 avril 2021]. Disponible : https://www.albertahealthservices.ca/assets/info/ppih/if-ppih-covid-19-sag-rapid-review-vitamin-d-treatment-and-prevention-covid-19.pdf

Google Scholar

85. Santé publique Ontario. Association of Vitamin D Status with COVID-19 Incidence and Outcomes, and Health Equity Considerations [En ligne]. 2021 [cité le 9 avril 2021]. Disponible : https://www.publichealthontario.ca/-/media/documents/ncov/he/2021/02/covid-19-rapid-review-vitamin-d.pdf?la=en

Google Scholar

86. Institut national d’excellence en santé et en services sociaux (INESSS). COVID-19 et Vitamine D [En ligne]. 2021 [cité le 9 avril 2021]. Disponible : https://www.inesss.qc.ca/fileadmin/doc/INESSS/COVID-19/COVID-19_INESSS_Vitamine_D.pdf

Google Scholar

87. Ostéoporose Canada. Calcium et vitamine D [En ligne]. 2020 [cité le 9 avril 2021]. Disponible : https://osteoporosecanada.ca/sante-des-os-et-osteoporose/calcium-et-vitamine-d/

Google Scholar

Revue du rôle possible de la vitamine D dans le traitement de la COVID-19 et recommandations pratiques[Record]

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