Résumés
Résumé
Le facteur de transcription TBP (TATA-binding protein) est une sous-unité de plusieurs complexes macromoléculaires nécessaires à la transcription par les trois ARN polymérases nucléaires. Cette observation avait conduit à faire de TBP un facteur « universel » de la transcription. La dé-couverte de trois protéines apparentées à TBP, et d’un complexe macromoléculaire dépourvu de TBP, mais capable d’initier la transcription par l’ARN polymérase II in vitro, a conduit à remettre en cause le caractère universel de TBP. Plusieurs études in vivo ont montré que TBP a plutôt un rôle specifique dans l’activation de certains gènes impliqués dans la prolifération cellulaire. De plus, le domaine aminoterminal de TBP joue un rôle dans l’établissement de la tolérance foetomaternelle.
Summary
The TATA binding protein (TBP) is a subunit of several macromolecular complexes required for transcription by the three nuclear RNA polymerases. This observation led to the idea that TBP is a « universal » transcription factor. The discovery of three TBP-related factors and a macromolecular complex which lacks TBP but can support RNA polymerase II transcription in vitro has led to a reappraisal of the universal character of TBP. Several in vivo studies have rather shown that TBP plays a specific role in the activation of a subset of cellular genes controlling the cell cycle. In mammals, the aminoterminal region of TBP plays a highly selective role in the maternal immunotolerance of pregnancy.
Parties annexes
Références
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