Résumés
Résumé
Les récepteurs couplés aux protéines G sont, pour la plupart, rapidement internalisés après stimulation. L’étude de ce phénomène s’est particulièrement développée depuis une dizaine d’années et a engendré une masse impressionnante d’informations, apparemment discordantes, qui pourraient faire croire que chaque récepteur interprète sa propre partition biologique. Le but de cet article est de souligner, à partir de travaux récents, les convergences qui existent au niveau de la fonction et des mécanismes de lde ces récepteurs, tout en soulignant certaines variations phénotypiques réelles qui reflètent des nécessités biologiques.
Summary
Most G protein-coupled receptors (GPCR) are rapidly internalized upon agonist stimulation. From the large number of studies available to date on receptor endocytosis, substantial differences seem to exist among GPCRs in terms of both the molecular pathways of receptor internalization and the biological significance of this process. The aim of this review is to outline common themes in GPCR endocytosis and to delineate true phenotypic variations, which reflect specific necessities for receptor’s function.
Parties annexes
Références
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