Résumés
Résumé
Des résultats indiquant des liaisons sur deux chromosomes pour la schizophrénie (SZ) et la maladie bipolaire (BP) furent trop hâtivement rapportés dans la revue Nature à la fin des années 1980. Les connaissances accumulées à partir des insuccès de la première génération d’études génétiques moléculaires de la SZ et de la BP ont toutefois permis de jeter les bases de la seconde génération d’études de liaison, qui donnent maintenant des résultats convergents fort encourageants. Cet article présente une douzaine de sites génomiques de susceptibilité pour la SZ et la BP, certains d’entre eux étant probablement partagés par ces deux psychoses majeures, tandis que d’autres seraient spécifiques à chacune.
Summary
Results claming linkage on two chromosomes for schizophrenia (SZ) and bipolar affective disorder (BP) were prematurely published in Nature at the end of the ‘80s. This ended up into disappointment. The knowledge accumulated from the first generation of unsuccessful molecular genetics studies of SZ and BP provided a stronger basis for the following generation of linkage studies that are now yielding encouraging converging results. Hence, we report several genomics susceptibility loci for SZ and BP, some of them being probably shared by the two major psychiatric illnesses whereas others could be specific to each.
Parties annexes
Références
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