Résumés
Résumé
Le foie, le rein et les tissus du système gastro-intestinal sont reconnus comme des sites majeurs qui conjuguent les composés exogènes en dérivés glucuronides par l’intermédiaire des UDP-glucuronosyltransférases (UGT). C’est un mécanisme extrêmement important dans l’élimination de la plupart de ces composés du corps humain. Des études récentes ont montré qu’en plus du foie et du rein, plusieurs glandes comme la prostate et la peau présentent un mécanisme de détoxification similaire, mais dont le but serait d’inactiver les stéroïdes. Une diminution d’activité des enzymes qui inactivent les stéroïdes pourrait provoquer une accumulation excessive du substrat et avoir des conséquences délétères sur ces tissus.
Summary
Liver, kidney, and gastrointestinal tissues are well known to express UDP-glucuronosyltransférase (UGT) enzymes which conjugate exogenous compounds. This mechanism is extremely important to eliminate several compounds from the body. Recent studies have shown that, in addition to the liver and kidney, a large number of tissues, namely the prostate and skin, also express UGT which are capable of inactivating steroids. This mechanism may be a means to modulate the action of steroids in these tissues.
Parties annexes
Références
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