Abstracts
Résumé
La matrilysine 1 (matrix metalloproteinase7, MMP7) a une importance considérable dans la progression des cancers, notamment digestifs, non seulement parce qu’elle exerce un rôle direct de dégradation sur des molécules cibles à différents niveaux, mais aussi parce qu’elle intervient dans l’activation d’autres systèmes protéolytiques. Son expression, faible dans les tissus sains, augmente très nettement au cours des proliférations cellulaires bénignes de type adénome, pour croître encore dans les cancers et être impliquée aussi bien au niveau du développement tumoral qu’à celui de la prolifération métastatique. Elle agit aux différentes étapes de la transformation maligne en clivant la E-cadhérine, molécule d’adhérence intercellulaire des épithéliums, ainsi que les molécules matricielles à l’interface tumeur-stroma et les intégrines qui les unissent aux cellules épithéliales. L’utilisation d’oligonucléotides antisens pour la MMP7 entraîne une nette diminution des processus invasifs, suggérant ainsi un potentiel thérapeutique important.
Summary
Matrilysin-1 has a considerable importance in the progression of cancers, namely digestive, ones inasmuch as it fulfils a direct function of deterioration on molecular targets at different levels and interfears as well in the activation of other proteolytic systems. Its low expression in sound tissues increases distinctly in mild cellular proliferations like adenomas to increase even more in carcinomas and be involved at the level of tumoral development as well as in a metastatical proliferation. It acts during the different stages of malignant transformation, splitting the E-cadherin, an intercellular adhesive molecule of epithelia, matrix molecules in the tumor-stroma interface and integrins which link matrix components to epithelial cells. The use of oligonucleotide antisens to the matrilysin-1 drives to a clear reduction of invading process, suggesting therefore an important therapeutic potential.
Appendices
Références
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