Abstracts
Résumé
La localisation intracellulaire des ARN est, dans de nombreuses espèces, impliquée dans les phénomènes de polarité cellulaire. Le plus souvent, l’ARN se localise en fonction d’une polarité préexistante et n’influence pas cette asymétrie. Cependant, dans le cas de l’actine β des vertébrés, le transport et la localisation de cet ARN sont directement impliqués dans l’établissement et le maintien de la polarisation cellulaire. Cela est vrai dans des cellules fibroblastiques en déplacement, mais aussi lors de la croissance axonale des neurones immatures. De manière remarquable, une altération du transport de cet ARN pourrait être liée à l’apparition de maladies chez l’homme. Cet article décrit l’état actuel des connaissances sur le rôle et les mécanismes de la localisation de l’ARNm de l’actine β.
Summary
In many species, intracellular mRNA localization is linked to cell polarity. In many cases however, mRNAs become localized as a result of a pre-existing cell-polarity, and they do not modify it. Remarkably, in the case β actin mRNA in vertebrate, it has been shown that the transport and localization of this RNA is required for the establishment and maintenance of cell polarity. This occurs in fibroblasts, but, very interestingly, in immature neurons as well. This review will describe the functions and mechanisms of actin mRNA localization.
Appendices
Références
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