Abstracts
Résumé
La découverte récente de la voie Patched/Sonic Hedgehog et de son rôle dans la prédisposition génétique et dans l’oncogenèse du carcinome basocellulaire ont permis des avancées majeures dans la compréhension de la genèse de cette tumeur. Pour la première fois, des modèles murins de carcinome basocellulaire ont été développés, qui devraient permettre, d’une part, de mieux comprendre les autres mécanismes moléculaires impliqués et, d’autre part, de tester de nouvelles stratégies thérapeutiques préventives ou curatives, pour tenter de maîtriser les formes multiples de carcinome basocellulaire, souvent invalidantes.
Summary
The recent discovery of the role of the Patched Sonic Hedgehog pathway in the physiopathogeny of BCC (basocellular carcinoma) and Gorlin’s syndrome has greatly improved our knowledge on the mechanism of development of these tumors. For the first time, murine models have been developed allowing to further understand other molecular events implicated in such tumors as well as providing in vivo models to search for new curative or preventive therapeutical strategies which would be helpful to control CBC multiple forms, that are often disabling.
Appendices
Références
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