Abstracts
Résumé
Les épithéliums qui bordent le tubule contourné proximal, le feuillet viscéral du sac vitellin et l’iléon ont la capacité d’internaliser par endocytose une grande variété de composants, notamment protéiques, qui permet leur approvisionnement en composés cruciaux, mais aussi le transport sélectif de composés d’un compartiment vers un autre. Un récepteur multiligands, la cubiline, en association avec la mégaline, un autre récepteur multiligands, joue un rôle crucial dans ces processus, en physiologie comme en pathologie.
Summary
Epithelia which line the renal proximal convoluted tubule, the visceral layer of the yolk sac and the ileum have the ability to internalize a variety of substances which not only serve as nutrients, but may also be transported from one compartment to another. Cubilin, a multiligand receptor, in association with megalin, also a multiligand receptor, appears to be important under both normal and pathological conditions.
Appendices
Références
- 1. Jollie WP. Development, morphology, and function of the Yolk-Sac placenta of laboratory rodents. Teratology 1990; 41: 361-81.
- 2. Christensen EI, Birn H, Verroust P, et al. Membrane receptors for endocytosis in renal proximal tubule. Int Rev Cytol 1998; 180: 237-84.
- 3. Seetharam B, Levine JS, Ramasamy M, et al. Purification, properties, and immunochemical localization of a receptor for intrinsic factor-cobalamin complex in the rat kidney. J Biol Chem 1988; 263: 4443-9.
- 4. Seetharam B, Christensen EI, Moestrup SK, et al. Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor. J Clin Invest 1997; 99: 2317-22.
- 5. Kozyraki R, Kristiansen M, Silahtaroglu A, et al. The human intrinsic factor-vitamin B12 receptor, cubilin: molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region. Blood 1998; 91: 3593-600.
- 6. Moestrup SK, Kozyraki R, Kristiansen M, et al. The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins. J Biol Chem 1998; 273: 5235-42.
- 7. Xu D, Kozyraki R, Newman TC, et al. Genetic evidence of an accessory activity required specifically for cubilin brush-border expression and intrinsic factor-cobalamin absorption. Blood 1999; 94: 3604-6.
- 8. Kristiansen M, Kozyraki R, Jacobsen C, et al. Molecular dissection of the intrinsic factor-vitamin B12 receptor, cubilin, discloses regions important for membrane association and ligand binding. J Biol Chem 1999; 274: 20540-4.
- 9. Ramanujam KS, Seetharam S, Dahms NM, et al. Effect of processing inhibitors on cobalamin (vitamin B12) transcytosis in polarized opossum kidney cells. Arch Biochem Biophys 1994; 315: 8-15.
- 10. Sahali D, Mulliez N, Chatelet F, et al. Comparative immunochemistry and ontogeny of two closely related coated pit proteins. The 280-kd target of teratogenic antibodies and the 330-kd target of nephritogenic antibodies. Am J Pathol 1993; 142: 1654-67.
- 11. Baricault L, Galceran M, Ronco PM, et al. Unusual processing of GP280, a protein associated with the intermicrovillar areas of yolk sac epithelial cells: plasma membrane delivery of immature protein. Biochem Biophys Res Commun 1995; 212: 353-9.
- 12. Fyfe JC, Ramanujam KS, Ramaswamy K, et al. Defective brush-border expression of intrinsic factor-cobalamin receptor in canine inherited intestinal cobalamin malabsorption. J Biol Chem 1991; 266: 4489-94.
- 13. Kozyraki R, Fyfe J, Kristiansen M, et al. The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein. Nat Med 1999; 5: 656-61.
- 14. Kozyraki R, Fyfe J, Verroust PJ, et al. Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia. Proc Natl Acad Sci USA 2001; 98: 12491-6.
- 15. Nykjaer A, Fyfe JC, Kozyraki R, et al. Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3). Proc Natl Acad Sci USA 2001; 98: 13895-900.
- 16. Burmeister R, Boe IM, Nykjaer A, et al. A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney. J Biol Chem 2001; 276: 13295-301.
- 17. Aminoff M, Carter JE, Chadwick RB, et al. Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1. Nat Genet 1999; 21: 309-13.
- 18. Birn H, Fyfe JC, Jacobsen C, et al. Cubilin is an albumin binding protein important for renal tubular albumin reabsorption. J Clin Invest 2000; 105: 1353-61.
- 19. Ruggenenti P, Remuzzi G. The role of protein traffic in the progression of renal diseases. Annu Rev Med 2000; 51: 315-27.
- 20. Moestrup SK, Birn H, Fischer PB, et al. Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis. Proc Natl Acad Sci USA 1996; 93: 8612-7.
- 21. Nykjaer A, Dragun D, Walther D, et al. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell 1999; 96: 507-15.
- 22. Sahali D, Mulliez N, Chatelet F, et al. Characterization of a 280-kD protein restricted to the coated pits of the renal brush border and the epithelial cells of the yolk sac. Teratogenic effect of the specific monoclonal antibodies. J Exp Med 1988; 167: 213-8.
- 23. Le Panse S, Ayani E, Mulliez N, et al. Antibodies to the 280-kD coated pit protein, target of teratogenic antibodies, produce alterations in the traffic of internalized proteins. Am J Pathol 1994; 145: 1526-36.
- 24. Beddington RS, Robertson EJ. Axis development and early asymmetry in mammals. Cell 1999; 96: 195-209.
- 25. Willnow TE, Hilpert J, Armstrong SA, et al. Defective forebrain development in mice lacking gp330/megalin. Proc Natl Acad Sci USA 1996; 93: 8460-4.