Abstracts
Résumé
La découverte de l’existence des gènes Cdc (cell division cycle) et des complexes cycline:Cdk, et de leur conservation dans l’évolution a valu à Leland H. Hartwell, Paul M. Nurse et R. Timothy Hunt le prix Nobel de physiologie et de médecine en 2001. Cet article fait le point des connaissances actuelles sur les molécules de régulation du cycle cellulaire, et met en avant l’importance de ces connaissances dans la compréhension des mécanismes responsables des cancers et dans le développement de nouvelles thérapeutiques en oncologie.
Summary
Leland H. Hartwell, Paul M. Nurse et R. Timothy Hunt just received the Nobel price for their discovery of the molecular components of the cell cycle and cell cycle checkpoints. This review is an update of the molecular networks driving the cell cycle and its regulation, and of the importance of this knowledge for understanding the mechanisms driving oncogenesis and therapeutic developments.
Appendices
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