Abstracts
Résumé
Bien que le traitement hormonal substitutif (hormone replacement therapy, HRT) soit le traitement le plus efficace des symptômes associés à la ménopause, des études plus récentes et plus rigoureuses confirment que les risques associés au HRT peuvent dépasser les bénéfices escomptés. Dans ce contexte, de plus en plus de femmes se tournent vers des solutions dites «naturelles», comme les phytooestrogènes, afin de soulager les malaises associés à la ménopause. Cet article passe en revue les effets des phytooestrogènes sur la réduction de ces symptômes et sur les risques de maladies cardiovasculaires, d’ostéoporose et de cancer du sein.
Summary
Many women seek alternatives to hormone replacement therapy (HRT). Phytoestrogens are nonsteroidal compounds with estrogenic or antiestrogenic properties. Six of the 16 clinical trials suggest a significant reduction in alleviating symptoms but to a lesser degree than HRT. A meta-analysis showed that phytoestrogens improve lipid profile. The 14 recent clinical trials led, however, to divergent findings. Small clinical trials suggested a protective effect of phytoestrogens on bone metabolism. High concentration of phytoestrogens was associated with a reduction in breast cancer risk in case-control studies.
Appendices
Références
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